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Gender Selection / Determination
Gender determination or selection is only possible with the IVF treatment. After IVF treatment, the sex of the baby can be determined with the genetic screening of the embryo. After the result the desired embryo(s) can be transferred to the mother – to- be. The success rate of determining the right gender is close to 100%, but the pregnancy success rate depends on the age and egg quality of the patient. Although gender selection is technically possible, it is prohibited in many countries and can only be done with permission in case of medical necessity.
We use two different methods to screen the embryo before implantation, these are PGD (Pre-implantation Genetic Screening) and NGS (Next Genetation Sequencing). These methods aim to screen the embryos’ chromosomally to see the health status as well as the sex chromosomes.
PGD (Pre-implantation Genetic Screening)
PGD testing is a procedure that allows certain chromosomes of the embryo to be tested before implantation. These chromosomes are Chromosome 13, 18, 21, X and Y. On day 3 of embryo development, embryologists take a biopsy of 1-2 cells from the embryos that reach the biopsy stage and these biopsies are sent for genetic screening. As a limited number of chromosomes are tested, the results are ready within few days and the suitable embryo(s) can be transferred to the patient. In terms of budget PGD is themost cost effective method.
NGS (Next Generation Sequencing)
NGS testing is a procedure that allows all 23 pairs chromosomes of the embryo to be tested before implantation.
With the NGS method,the embryos are screened quickly and effectively meaning that any genetic problems are detected on a chromosomal level before implantation and pregnancy. The results of this test are ready in 3-4 weeks and embryo transfer can be planned for the next cycle. This is a very popular method used by families who want detailed genetic screening before embryo transfer.
What Tests are Required for this Method?
The tests required for this method are exactly the same as those required for couples that will undergo IVF treatment even though they have conceived and had a successful pregnancy before. These tests will give preliminary information about a couples suitability for the treatment and the chances of success. After the test results are received, a treatment protocol is set by taking into consideration the patients’ egg reserve and age. The treatment starts with day 2 or 3 of the cycle and lasts around 10-15 days depending on how the patient reacts to the medication. This part of the treatment can be started at home.The aim of this procedure is to stimulate and increase the single maturing egg of the woman in the normal menstrual cycle with the help of medication and to increase the success of the couple in the IVF process. Eggs that have reached the desired maturity are collected in the laboratory environment with a light anesthesia. Collected eggs are fertilized with sperm using microinjection (ICSI). After fertilization, genetic screening is completed and the healthy embryo(s) can be transferred to the mother – to – be. Couples that have achieved pregnancy before have a greater chance of success. For young mothers, very successful results can be obtained with gender selection treatment.